Medical Care Supplement

Table of Contents
Medical Care 2007 Oct;45(Suppl 2).

Editorials

• Preface
  Smith SR. Preface. Medical Care. 2007 Oct;45(Suppl 2):S1-S2.
• The Comparative Effectiveness and Safety Emerging Methods Symposium: A Tribute to Harry A. Guess: Father and Consummate Leader of Pharmacoepidemiology
  Ballard DJ. The Comparative Effectiveness and Safety Emerging Methods Symposium: A Tribute to Harry A. Guess: Father and Consummate Leader of Pharmacoepidemiology. Medical Care. 2007 Oct;45(Suppl 2):S3-S4.

Original Articles

• Emerging Methods in Comparative Effectiveness and Safety: Symposium Overview and Summary
  Kathleen N. Lohr. Emerging Methods in Comparative Effectiveness and Safety: Symposium Overview and Summary. Med Care. 2007;45(Suppl 2): S5-S8.
• Medicare Part D Data: Major Changes on the Horizon
  Leslie M. Greenwald. Medicare Part D Data: Major Changes on the Horizon. Med Care. 2007;45(Suppl 2): S9-S12.
• Methodologic Challenges to Studying Patient Safety and Comparative Effectiveness
  Brian L. Strom. Methodologic Challenges to Studying Patient Safety and Comparative Effectiveness. Med Care. 2007;45(Suppl 2): S13-S15.
• Creating and Synthesizing Evidence With Decision Makers in Mind: Integrating Evidence From Clinical Trials and Other Study Designs
  David Atkins. Creating and synthesizing evidence with decision makers in mind: integrating evidence from clinical trials and other study designs. Med Care. 2007;45(Suppl 2): S16-S22.
• Improving Depiction of Benefits and Harms: Analyses of Studies of Well-Known Therapeutics and Review of High-Impact Medical Journals
  Artyom Sedrakyan, Chuck Shih, MHS. Improving Depiction of Benefits and Harms: Analyses of Studies of Well-known Therapeutics and Review of High-impact Medical Journals. Med Care. 2007;45(Suppl 2): S23-S28.
• Cluster Randomized Trials: Opportunities and Barriers Identified by Leaders of Eight Health Plans
  Kathleen M. Mazor, James E. Sabin, Denise Boudreau, Michael J. Goodman, Jerry H. Gurwitz, Lisa J. Herrinton, Marsha A. Raebel, Douglas Roblin, David H. Smith, Vanessa Meterko, Richard Platt. Cluster Randomized Trials: Opportunities and Barriers Identified by Leaders of Eight Health Plans. Med Care. 2007;45(Suppl 2): S29-S37.
• Design of Cluster-Randomized Trials of Quality Improvement Interventions Aimed at Medical Care Providers
  Robert J. Glynn, M. Alan Brookhart, Margaret Stedman, Jerry Avorn, and Daniel H. Solomon. Design of Cluster-Randomized Trials of Quality Improvement Interventions Aimed at Medical Care Providers. Med Care. 2007;45(Suppl 2): S38-S43.
• Designed Delays Versus Rigorous Pragmatic Trials: Lower Carat Gold Standards Can Produce Relevant Drug Evaluations
  Malcolm Maclure, Bruce Carleton, Sebastian Schneeweiss. Designed Delays vs Rigorous Pragmatic Trials: Lower Carat Gold Standards Can Produce Relevant Drug Evaluations. Med Care. 2007;45(Suppl 2): S44-S49.
• Practice-Based Evidence Study Design for Comparative Effectiveness Research
  Susan D. Horn, Julie Gassaway. Practice-Based Evidence Study Design for Comparative Effectiveness Research. Med Care. 2007;45(Suppl 2): S50-S57.
• Studying Prescription Drug Use and Outcomes With Medicaid Claims Data: Strengths, Limitations, and Strategies
  Stephen Crystal, Ayse Akincigil, Scott Bilder, and James T. Walkup. Studying Prescription Drug Use and Outcomes with Medicaid Claims Data: Strengths, Limitations, and Strategies. Med Care. 2007;45(Suppl 2): S58-S65.
• Assessment of Adherence to and Persistence on Disease-Modifying Antirheumatic Drugs (DMARDs) in Patients With Rheumatoid Arthritis
  Carlos G. Grijalva, Cecilia P. Chung, Nakandakari, Patrick G. Arbogast, Charles M. Stein, Edward F. Mitchel Jr., Marie R. Griffin. Assessment of Adherence to and Persistence on Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Patients with Rheumatoid Arthritis. Med Care. 2007;45(Suppl 2): S66-S76.
• Out-of-Pocket Pharmacy Expenditures for Veterans Under Medicare Part D
  Randall W. Rupper, Byron D. Bair, Brian C. Sauer, Jonathan Nebeker, Judith Shinogle, Matthew Samore, MD. Out-of-pocket Pharmacy Expenditures for Veterans under Medicare Part D. Med Care. 2007;45(Suppl 2): S77-S80.
• Developing Indicators of Inpatient Adverse Drug Events Through Nonlinear Analysis Using Administrative Data
  Jonathan R. Nebeker, Paul R. Yarnold, PhD, Robert C. Soltysik, Brian C. Sauer, Shannon A. Sims, Matthew H. Samore, Randall W. Rupper, Kathleen M. Swanson, Lucy A. Savitz, Judith Shinogle, Wu Xu. Developing Indicators of Inpatient Adverse Drug Events Through Non-Linear Analysis Using Administrative Data. Med Care. 2007;45(Suppl 2): S81-S88.
• Real-Time Vaccine Safety Surveillance for the Early Detection of Adverse Events
  Tracy A. Lieu, Martin Kulldorff, Robert L. Davis, Edwin M. Lewis, Eric Weintraub, Katherine Yih, Ruihua Yin, Jeffrey S. Brown, and Richard Platt, for the Vaccine Safety Datalink Rapid Cycle Analysis Team. Real-Time Vaccine Safety Surveillance for the Early Detection of Adverse Events. Med Care. 2007;45(Suppl 2): S89-S95.
• Evaluation and Overview of the National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance Project (NEISS-CADES)
  Michael A. Jhung, Daniel S. Budnitz, Aaron B. Mendelsohn. Evaluation and overview of the National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance Project (NEISS-CADES). Med Care. 2007;45(Suppl 2): S96-S102.
• Using Inverse Probability-Weighted Estimators in Comparative Effectiveness Analyses With Observational Databases
  Lesley H. Curtis, Bradley G. Hammill, Eric L. Eisenstein, Judith M. Kramer, Kevin J. Anstrom. Using Inverse Probability-Weighted Estimators in Comparative Effectiveness. Analyses With Observational Databases. Med Care. 2007;45(Suppl 2): S103-S107.
• A Simulation-Based Evaluation of Methods to Estimate the Impact of an Adverse Event on Hospital Length of Stay
  Matthew H. Samore, Jonathan Nebeker, Stephan Harbarth, Tom Greene, Brian Sauer, Judith Shinogle, Greg Stoddard, Shuying Shen. A Simulation-Based Evaluation of Methods to Estimate the Impact of an Adverse Event on Hospital Length of Stay. Med Care. 2007;45(Suppl 2): S108-S115.
• Evaluating the Validity of an Instrumental Variable Study of Neuroleptics: Can Between-Physician Differences in Prescribing Patterns Be Used to Estimate Treatment Effects?
  M. Alan Brookhart, Jeremy A. Rassen, Philip S. Wang, Colin Dormuth, Helen Mogun, and Sebastian Schneeweiss. Evaluating the Validity of an Instrumental Variable Study of Neuroleptics. Can Between-Physician Differences in Prescribing Patterns Be Used to Estimate Treatment Effects? Med Care. 2007;45(Suppl 2): S116-S122.
• Heterogeneity and the Interpretation of Treatment Effect Estimates From Risk Adjustment and Instrumental Variable Methods
  John M. Brooks, Elizabeth A Chrischilles. Heterogeneity and Treatment Effect Estimates from Risk-Adjustment and Instrumental Variable Methods: Surgery for Early-Stage Breast Cancer. Med Care. 2007;45(Suppl 2): S123-S130.
• Increasing Levels of Restriction in Pharmacoepidemiologic Database Studies of Elderly and Comparison With Randomized Trial Results
  Sebastian Schneeweiss, Amanda R Patrick, Til Strmer, M Alan Brookhart, Jerry Avorn, Malcolm Maclure, Kenneth J Rothman, Robert J Glynn. Increasing Levels of Restriction in Pharmacoepidemiologic Database Studies of Elderly and Comparison with Randomized Trial Results. Med Care. 2007;45(Suppl 2): S131-S142.
• Use of Propensity Score Technique to Account for Exposure-Related Covariates: An Example and Lesson
  John D. Seeger, Tobias Kurth, Alexander M. Walker. Use of Propensity Score Technique to Account for Exposure-Related Covariates: An Example and Lesson. Med Care. 2007;45(Suppl 2): S143-S148.
• Using Propensity Scores Subclassification to Estimate Effects of Longitudinal Treatments: An Example Using a New Diabetes Medication
  Jodi B Segal, Michael Griswold, Aristide Achy-Brou, Robert Herbert, Eric B. Bass, Sydney Dy, E. Anne Millman, Albert W. Wu, , Constantine Frangakis Using Propensity Scores Subclassification to Estimate Effects of Longitudinal Treatments: An Example Using a New Diabetes Medication. Med Care. 2007;45(Suppl 2): S149-S157.
• Adjustments for Unmeasured Confounders in Pharmacoepidemiologic Database Studies Using External Information
  Til Stürmer, Robert J Glynn, Kenneth J Rothman, Jerry Avorn, Sebastian Schneeweiss. Adjustments for Unmeasured Confounders in Pharmacoepidemiologic Database Studies Using External Information. Med Care. 2007;45(Suppl 2): S158-S165.
• Comparison of Meta-Analytic Results of Indirect, Direct, and Combined Comparisons of Drugs for Chronic Insomnia in Adults: A Case Study
  Benjamin W Vandermeer, Nina Buscemi, Yuanyuan Liang, Manisha Witmans. Comparison of Meta-Analytic Results of Indirect, Direct, and Combined Comparisons of Drugs for Chronic Insomnia in Adults: A Case Study. Med Care. 2007;45(Suppl 2): S166-S172.