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- Data Points #4: Trends in the utilization of erythropoiesis-stimulating agents among Medicare beneficiaries with kidney disease
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- Data Points Publication Series
- Data Points #1: Prevalence of diabetes, diabetic foot ulcer, and lower extremity amputation among Medicare beneficiaries, 2006-2008.
- Data Points #2: Incidence of diabetic foot ulcer and lower extremity amputation among Medicare beneficiaries, 2006-2008.
- Data Points #3: Economic burden of diabetic foot ulcers and amputations
- Data Points #5: Prevalence and Medicare Reimbursement by Recurrent International Classification of Diseases Categories, 2006-2009
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- Data Points #9: Utilization of antidiabetic drugs among Medicare beneficiaries with diabetes, 2006-2009
- Data Points #10: Proton beam radiotherapy in the U.S. Medicare population: growth in use between 2006 and 2009
- Data Points #11: Newly Medicare-eligible disabled: comparison of duals and nonduals
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- Data Points #15: Prognostic factor testing among older women with ductal carcinoma in situ and early invasive breast cancer
- Data Points #16: Changes across time and geography in the use of prostate radiation technologies for newly diagnosed older cancer patients: 2006-2008
- Data Points #18: Use of and access to health care by Medicare beneficiaries with diabetes: impact of diabetes type and insulin use, 2007-2011
- Data Points #17: Trends in bariatric surgery in Medicare beneficiaries
- Data Points #19: Medication Use in Medicare
- Data Points #20: Echocardiography Trends
Research Report - Final – Mar. 31, 2011
Data Points #4: Trends in the utilization of erythropoiesis-stimulating agents among Medicare beneficiaries with kidney disease
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Note: This report is greater than 5 years old. Findings may be used for research purposes but should not be considered current.
The findings described herein were presented by Thomas MaCurdy, Ph.D., at the Medicare Evidence Development & Coverage Advisory Committee meeting held on March 24, 2010, in Baltimore, Maryland.
Chronic renal disease affects more than 26 million Americans and is the cause of significant morbidity, hospitalization, and mortality. Anemia, a common complication, conveys significant risk for cardiovascular disease, faster progression of renal failure, and decreased quality of life. In fact, most patients with chronic renal disease become anemic. Correction of anemia in such patients is associated with improved outcomes, such as forestalling target organ damage.
Erythropoiesis-stimulating agents (ESAs) are recombinant hematopoietic drugs that stimulate the production of red blood cells. Epoetin alfa received Food and Drug Administration (FDA) approval in 1989, with darbepoetin alfa following in 2001. Thereby, modalities became available for the treatment of anemia in chronic renal failure, chemotherapy-treated cancer, and zidovudine-treated HIV-infected patients. Furthermore, ESAs have allowed the reduction of allogeneic blood transfusions in surgery patients. ESA dosing is individualized to achieve and maintain hemoglobin levels within the range of 10 to 12 grams per dL.5 A number of published studies, beginning in the late 1990s, suggested potential adverse cardiovascular outcomes arising from ESA therapy. Studies amassing over the past decade have led to a number of clinical and policy changes regarding the use of ESAs.
The goal of this Data Points brief was to examine practice trends in the use of ESAs among Medicare beneficiaries with kidney disease (KD) and to relate these trends to the timing of clinical practice and policy events that had the potential to affect ESA use. Secondarily, we examined the use of ESAs in a subpopulation of beneficiaries with KD and cancer.
The work described herein was commissioned for presentation at the March 24, 2010, Medicare Evidence Development & Coverage Advisory Committee meeting to discuss ESAs in anemia related to KD. Additional information on this meeting, including the agenda, presentations, and meeting minutes, can be found at: www.cms.gov/FACA/02_MEDCAC.asp