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Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults

Slide: 21 of 28

Findings of the Comparative Effectiveness Review: VNS

In a mixed MDD/bipolar population, evidence of low strength indicates that VNS does not clearly differ from sham treatment with respect to improvements in depression severity, response rates, or daily functioning. However, VNS may produce increased rates of some specific adverse effects (commonly reported adverse effects associated with VNS include voice alteration, cough, neck pain, paresthesia, and dyspnea), and VNS may result in a greater number of withdrawals attributed to adverse events.