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First- and Second-Generation Antipsychotics for Children and Young Adults

Slide: 14 of 43

Clinically Significant Outcomes of Interest in the Comparative Effectiveness Review

Both core illness symptoms and nonspecific symptoms were of interest in the systematic review.

A wide variety of common psychiatric assessment instruments are used to evaluate symptoms in studies of pediatric use of antipsychotics. These included:

  • The Aberrant Behavior Checklist (ABC), which evaluates treatment effects on profoundly mentally retarded participants
  • The Brief Psychiatric Rating Scale–Children (BPRS-C), which evaluates childhood psychiatric disorders and response to treatment
  • The Children’s Depression Rating Scale (CDRS), which evaluates the severity of depression in children 6–12 years of age
  • The Children’s Global Assessment Scale (CGAS), which is an overall measure of disturbance used for children 4–16 years of age
  • The Clinical Global Impressions (CGI), which evaluates the global rating of severity (-S), improvement (-I), or overall impression
  • The Nisonger Child Behavior Rating Form (NCBRF), which evaluates childhood problems because of mental retardation
  • The Overt Aggression Scale (OAS), which evaluates physical and verbal aggressive behaviors
  • The Positive and Negative Syndrome Scale (PANSS), which evaluates positive and negative symptoms in schizophrenia
  • The Young Mania Rating Scale (YMRS), which evaluates the severity (not diagnosis) of mania