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First- and Second-Generation Antipsychotics for Children and Young Adults
Authors: John H. Coverdale, MD, MEd
Adverse Events of Interest in the Comparative Effectiveness Review
Adverse events data extracted from published studies included:
- Cardiac and cerebrovascular events
- Weight and body composition
- Insulin resistance and diabetes
- Prolactin-related and sexual effects
- Neuromotor (extrapyramidal)
- Liver toxicity
- Neutropenia and agranulocytosis
- Thyroid dysfunction
- Neuroleptic malignant syndrome
- Exercise intolerance
- Precocious puberty
- Behavioral effects
- Dermatological effects
For adverse events reporting, standardized instruments that evaluate extrapyramidal symptoms are also used in clinical trials.
- Seida J, Schouten J, Mousavi S, et al. First- and Second-Generation Antipsychotics for Children and Young Adults. Comparative Effectiveness Review No. 39 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; February 2012. AHRQ Publication No. 11(12)-EHC077-EF. Available at www.effectivehealthcare.ahrq.gov/pedantipsych.cfm.
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