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First- and Second-Generation Antipsychotics for Children and Young Adults

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Outline of Material

The material begins with an introduction to pediatric use of first-generation and second-generation antipsychotics, including approved and off-label indications.

The systematic review methods used to develop the comparative effectiveness review are presented. The clinical questions addressed by the comparative effectiveness review are also presented, followed by the results of studies and evidence-based conclusions about effectiveness and adverse effects of antipsychotics in pediatric use.

Gaps in knowledge revealed by the review process are discussed. Some suggestions are made for what to discuss with patients and their caregivers, based on the review findings.