Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Comparative Effectiveness of Pharmacological Prophylaxis Agents: UFH Versus Desirudin
The relative risk for DVT events is higher for injectable UFH versus desirudin [RR 2.31 (95% CI 1.34 to 4.00)].
- The relative risk for DVT events is higher for injectable UFH versus desirudin in THR surgery.
The odds for proximal DVT events is higher for injectable UFH versus desirudin [OR 4.74 (95% CI 2.99 to 7.49)].
- The odds for proximal DVT events is higher for injectable UFH versus desirudin in THR surgery.
Abbreviations: 95% CI = 95-percent confidence interval; DVT = deep vein thrombosis; OR = odds ratio; RR = relative risk; THR = total hip replacement; UFH = unfractionated heparin
Keywords: bleeding | deep vein thrombosis | desirudin | low-molecular-weight heparin | magnitude of effect | pharmacological prophylaxis | pulmonary embolism | strength of evidence | total hip replacement | total knee replacement | unfractionated heparin | venous thromboembolism | warfarin | orthopedic surgery
- Sobieraj DM, Coleman CI, Tongbram V, et al. Venous Thromboembolism in Orthopedic Surgery. Comparative Effectiveness Review No. 49 (Prepared by the University of Connecticut/Hartford Hospital Evidence-based Practice Center under Contract No. 290-2007-10067-I). Rockville, MD: Agency for Healthcare Research and Quality; March 2012. AHRQ Publication No. 12-EHC020-EF. Available at www.effectivehealthcare.ahrq.gov/thrombo.cfm.
Your slide tray is being processed.