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Venous Thromboembolism Prophylaxis in Orthopedic Surgery

Slide: 28 of 30

Gaps in Knowledge

Inadequate data did not permit conclusions about the comparative benefits and adverse effects associated with venous thromboprophylaxis in non–joint-replacement surgery.

More information is needed on the following aspects of VTE prophylaxis in the setting of major orthopedic surgery:

  • Clinically important outcomes including symptomatic venous thromboembolism, post-thrombotic syndrome, clinically relevant bleeding, prosthetic infection, reoperation, and mortality and whether intermediate outcomes predict health outcomes
  • Surgical, postsurgical, or patient factors that predict outcomes
  • The optimal followup period needed to determine longer term outcomes
  • Optimal duration of VTE prophylaxis
  • The role of combined pharmacological and mechanical prophylaxis