Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Rating the Strength of Evidence From the Comparative Effectiveness Review
The Evidence-based Practice Center GRADE approach, based on the standard GRADE approach, was used to assess the quality of the body of evidence for each outcome. The overall strength of evidence was graded as high (high confidence that the evidence reflects the true effect; further research is very unlikely to change our confidence in the estimate of effect), moderate (moderate confidence that the evidence reflects the true effect; further research may change our confidence in the estimate of effect and may change the estimate), low (low confidence that the evidence reflects the true effect; further research is likely to change our confidence in the estimate of effect and is likely to change the estimate), or insufficient (evidence is either unavailable or does not permit estimation of an effect). The authors also independently evaluated the applicability to real-world practice of the total body of evidence within a given clinical indication using the PICOTS framework (population, intervention, comparator, outcome, timing, and setting).
Keywords: strength of evidence | comparative effectiveness review | Evidence-based Practice Center | EPC | GRADE | applicability | PICOTS
- Agency for Healthcare Research and Quality. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Rockville, MD: Agency for Healthcare Research and Quality; Prepublication Draft Copy April 2012. Available at www.effectivehealthcare.ahrq.gov/ehc/products/60/318/MethodsGuide_Prepublication-Draft_20120409.pdf.
- Sobieraj DM, Coleman CI, Tongbram V, et al. Venous Thromboembolism in Orthopedic Surgery. Comparative Effectiveness Review No. 49 (Prepared by the University of Connecticut/Hartford Hospital Evidence-based Practice Center under Contract No. 290-2007-10067-I). Rockville, MD: Agency for Healthcare Research and Quality; March 2012. AHRQ Publication No. 12-EHC020-EF. Available at www.effectivehealthcare.ahrq.gov/thrombo.cfm.
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