Second-Generation Antidepressants for Treating Adult Depression—An Update
Comparative Effectiveness of Second-Generation Antidepressants in Continuation and Maintenance Phases
This portion (slides 15–16) of the presentation addresses two key aspects of treating patients with major depressive disorder (MDD). First, the research presented in this section addresses maintenance of remissions and prevention of relapses or recurrences for patients who have responded to antidepressant treatment; the second issue the research addresses focuses on ongoing depressive disease for those who have not responded to such therapy or who have experienced relapses or new episodes. For patients who have responded, two subquestions are important: the efficacy or effectiveness of (1) continuing the initial (existing) medication or (2) switching to a different one. For patients who have not responded to treatment, the studies focus on using different antidepressants.
Keywords: continuation phase | maintenance phase | relapse | remission | resistant depression | refractory depression
- Gartlehner G, Hansen RA, Morgan LC, et al. Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression: An Update of the 2007 Comparative Effectiveness Review. Comparative Effectiveness Review No. 46 (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I). Rockville, MD: Agency for Healthcare Research and Quality; December 2011. AHRQ Publication No. 12-EHC012-EF. Available at www.effectivehealthcare.ahrq.gov/secondgenantidep.cfm.
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