Second-Generation Antidepressants for Treating Adult Depression—An Update
Comparative Effectiveness of Second-Generation Antidepressants in the Continuation and Maintenance Phases
For maintaining remission, there is moderate-strength evidence that most second-generation antidepressants effectively maintain remission (prevent relapse and recurrence) with similar efficacy. When treating resistant or refractory depression, there is low-strength evidence that venlafaxine may be modestly superior to other selective serotonin reuptake inhibitors; however, results on comparative effectiveness are mixed.
- Gartlehner G, Hansen RA, Morgan LC, et al. Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression: An Update of the 2007 Comparative Effectiveness Review. Comparative Effectiveness Review No. 46 (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I). Rockville, MD: Agency for Healthcare Research and Quality; December 2011. AHRQ Publication No. 12-EHC012-EF. Available at www.effectivehealthcare.ahrq.gov/secondgenantidep.cfm.
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