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Second-Generation Antidepressants for Treating Adult Depression—An Update

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Comparative Effectiveness of Second-Generation Antidepressants in the Continuation and Maintenance Phases

For maintaining remission, there is moderate-strength evidence that most second-generation antidepressants effectively maintain remission (prevent relapse and recurrence) with similar efficacy. When treating resistant or refractory depression, there is low-strength evidence that venlafaxine may be modestly superior to other selective serotonin reuptake inhibitors; however, results on comparative effectiveness are mixed.