Second-Generation Antidepressants for Treating Adult Depression—An Update
Effectiveness of Second-Generation Antidepressants in Treating Symptoms That May Accompany Depression
This portion (slides 17–18) of the presentation addresses the research focused on the comparative benefits of medications for patients with depression and an accompanying symptom cluster. Studies addressing seven symptom clusters were identified and included: anxiety, insomnia, low energy, pain, psychomotor change (retardation or agitation), melancholia (a depressive subtype that is a severe form of major depressive disorder with characteristic somatic symptoms), and somatization (physical complaints that are manifestations of depression rather than of an underlying physical illness). This set does not represent a complete list of symptoms that commonly accompany depression. For example, there were no included studies addressing appetite change—a common accompanying symptom reported by depressed patients.
- Gartlehner G, Hansen RA, Morgan LC, et al. Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression: An Update of the 2007 Comparative Effectiveness Review. Comparative Effectiveness Review No. 46 (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I). Rockville, MD: Agency for Healthcare Research and Quality; December 2011. AHRQ Publication No. 12-EHC012-EF. Available at www.effectivehealthcare.ahrq.gov/secondgenantidep.cfm.
Your slide tray is being processed.