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Second-Generation Antidepressants for Treating Adult Depression—An Update

Slide: 17 of 28

Effectiveness of Second-Generation Antidepressants in Treating Symptoms That May Accompany Depression

This portion (slides 17–18) of the presentation addresses the research focused on the comparative benefits of medications for patients with depression and an accompanying symptom cluster. Studies addressing seven symptom clusters were identified and included: anxiety, insomnia, low energy, pain, psychomotor change (retardation or agitation), melancholia (a depressive subtype that is a severe form of major depressive disorder with characteristic somatic symptoms), and somatization (physical complaints that are manifestations of depression rather than of an underlying physical illness). This set does not represent a complete list of symptoms that commonly accompany depression. For example, there were no included studies addressing appetite change—a common accompanying symptom reported by depressed patients.