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Second-Generation Antidepressants for Treating Adult Depression—An Update

Slide: 22 of 28

Specific Comparative Harms of Second-Generation Antidepressants for Adults With MDD (2 of 3)

The strength of evidence was moderate that trazodone was associated with a 16-percent higher incidence of somnolence than bupropion, fluoxetine, mirtazapine, paroxetine, and venlafaxine. High-strength evidence suggests that bupropion had fewer sexual side effects than escitalopram, fluoxetine, paroxetine, and sertraline. Moderate-strength evidence indicated that paroxetine had the highest rate of sexual side effects when compared with selective serotonin reuptake inhibitors as a class (16% vs. 6%). However, there was some low-strength evidence that sexual side effects may occur at different rates between men and women.