Second-Generation Antidepressants for Treating Adult Depression—An Update
Rating the Strength of Evidence From the Comparative Effectiveness Review
The Evidence-based Practice Center GRADE approach, based on the standard GRADE approach, was used to assess the quality of the body of evidence for each outcome. The overall strength of evidence was graded as high (high confidence that the evidence reflects the true effect; further research is very unlikely to change our confidence in the estimate of effect), moderate (moderate confidence that the evidence reflects the true effect; further research may change our confidence in the estimate of effect and may change the estimate), low (low confidence that the evidence reflects the true effect; further research is likely to change the confidence in the estimate of effect and is likely to change the estimate), or insufficient (evidence either is unavailable or does not permit a conclusion). The authors also independently evaluated the applicability to real-world practice of the total body of evidence within a given clinical indication using the PICOTS (population, intervention, comparator, outcome, timing, and setting) framework.
- Gartlehner G, Hansen RA, Morgan LC, et al. Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression: An Update of the 2007 Comparative Effectiveness Review. Comparative Effectiveness Review No. 46 (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I). Rockville, MD: Agency for Healthcare Research and Quality; December 2011. AHRQ Publication No. 12-EHC012-EF. Available at www.effectivehealthcare.ahrq.gov/secondgenantidep.cfm.
- Agency for Healthcare Research and Quality. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Rockville, MD: Agency for Healthcare Research and Quality; Prepublication Draft Copy April 2012. Available at www.effectivehealthcare.ahrq.gov/search-for-guides-reviews-and-reports/?pageaction=displayproduct&mp=1&productID=318.
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