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Second-Generation Antidepressants for Treating Adult Depression—An Update

Slide: 7 of 28

Background: Antidepressant Medications

In general, the efficacies of first- and second-generation antidepressant medications are similar and have been reported to be somewhere around 60 percent. However, first-generation antidepressants often produce multiple side effects that many patients find intolerable, and the risk for harm when taken in overdose or in combination with certain medications is high. Because of their relatively favorable side-effect profile, the second-generation antidepressants play a prominent role in managing patients with major depressive disorder and are the focus of this presentation.