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Off-Label Use of Atypical Antipsychotics: An Update

Slide: 2 of 47

Outline of Material

  • The material begins with an introduction to atypical antipsychotics and their use off-label.
  • The systematic review methods used to develop the comparative effectiveness review (CER) are presented.
  • The clinical questions addressed by the CER are presented, as well as a review of the modes of statistical analysis and results reporting in the CER.
  • The results of studies and evidence-based conclusions about effectiveness and adverse effects of atypical antipsychotics used off-label are presented.
  • Gaps in knowledge revealed by the review process are presented.
  • Some suggestions are made for what to discuss with patients and their caregivers, based on the CER findings.