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Off-Label Use of Atypical Antipsychotics: An Update

Slide: 23 of 47

Results: Atypical Antipsychotics for Obsessive-Compulsive Disorder

Atypical antipsychotics have been used to treat obsessive-compulsive disorder as augmentation of selective serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors. In comparisons with placebo for response rate measured with the YBOCS in 3 trials with a total of 97 subjects, risperidone resulted in 1 of every 5 patients demonstrating an improved YBOCS score. The strength of evidence for this finding is moderate.

In head-to-head trials of comparative effectiveness, olanzapine was compared with risperidone in 1 trial of 50 participants by using the YBOCS score. No statistically significant difference between treatments was detected. The strength of evidence for this finding is low.