Off-Label Use of Atypical Antipsychotics: An Update
Summary of Adverse Effects in Elderly Patients (2 of 2)
In elderly adults (65 and older), extrapyramidal symptoms are most common with risperidone and olanzapine. The strength of evidence for this finding is moderate.
Atypical antipsychotics are associated with sedative effects and fatigue. The strength of evidence for this finding is moderate.
Atypical antipsychotics elevate the risk of urinary adverse effects in elderly patients, but the evidence is too limited to permit conclusions about the degree of risk. The strength of evidence for this finding is low.
Keywords: antipsychotics | atypical antipsychotics | off-label | second generation | adverse effects | elderly | extrapyramidal symptoms | EPS | sedation | fatigue
- Maglione M, Ruelaz Maher A, Hu J, et al. Off-Label Use of Atypical Antipsychotics: An Update. Comparative Effectiveness Review No. 43 (Prepared by the Southern California RAND Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11(12)-EHC087-EF. Available at www.effectivehealthcare.ahrq.gov/offlabelantipsych.cfm.
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