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Off-Label Use of Atypical Antipsychotics: An Update

Slide: 40 of 47

Summary of Adverse Effects in Adults (1 of 2)

Antipsychotics in the atypical class generally promote weight gain in adults (ages 18–64) and in the elderly (ages ≥65), but olanzapine is associated with greater risk than typical or other atypical antipsychotics. For olanzapine, the number needed to harm is 3 versus 16–35 for other atypical antipsychotics.

Some atypical antipsychotics (olanzapine in particular) are associated with endocrine and metabolic abnormalities, but the degree of increased risk is not clear.