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Off-Label Use of Atypical Antipsychotics: An Update

Slide: 41 of 47

Summary of Adverse Effects in Adults (2 of 2)

The risk of extrapyramidal symptoms is elevated with aripiprazole (NNH = 11; akathisia, NNH =7), quetiapine (NNH = 36), and ziprasidone (NNH = 24) in adults (ages 18–64). The strength of evidence for these findings is low.

The risks of extrapyramidal symptoms with olanzapine and aripiprazole are about one-fourth of the risks for adult patients taking typical antipsychotics. The strength of evidence for these findings is low.

Atypical antipsychotics are associated with sedative effects and fatigue (sedation NNH = 3 for quetiapine, whereas others range from 6–11; fatigue NNH = 14–19) in adults. The strength of evidence for these findings is moderate.