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Off-Label Use of Atypical Antipsychotics: An Update

Slide: 46 of 47

Conclusions (3 of 3)

The risk of death in elderly patients (ages ≥65) is increased by both atypical and typical class antipsychotics. Adverse effects in both elderly and adult (ages 18–64) patients, not associated with age, include:

  • Increased risk of weight gain: more common and severe with olanzapine
  • Endocrine and metabolic abnormalities: risks are measurable but less certain
  • Sedative effects, fatigue
  • Extrapyramidal symptoms

The possibility of urinary adverse effects in elderly patients has appeared in studies of the atypical antipsychotics.