Off-Label Use of Atypical Antipsychotics: An Update
Clinical Questions Addressed by the Comparative Effectiveness Review (1 of 2)
The comparative effectiveness review addressed several key clinical questions, including: What are the leading off-label uses of atypical antipsychotics in utilization studies? How have trends in utilization changed in recent years, including inpatient versus outpatient use? What new uses are being studied in trials? What does the evidence show regarding the efficacy and comparative effectiveness of atypical antipsychotics for off-label indications? How do atypical antipsychotic medications compare with other drugs, including first-generation antipsychotics, for treating off-label indications?
Keywords: antipsychotics | atypical antipsychotics | off-label | second generation | utilization | comparative effectiveness | efficacy
- Maglione M, Ruelaz Maher A, Hu J, et al. Off-Label Use of Atypical Antipsychotics: An Update. Comparative Effectiveness Review No. 43 (Prepared by the Southern California RAND Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11(12)-EHC087-EF. Available at www.effectivehealthcare.ahrq.gov/offlabelantipsych.cfm.
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