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Insulin Delivery and Glucose Monitoring Methods for Diabetes Mellitus: Comparative Effectiveness

Slide: 11 of 25

Clinical Questions Addressed by the Comparative Effectiveness Review (2 of 2)

In preparing the report on which this presentation is based, the authors aimed to answer two Key Questions (KQs). KQ 2 is listed below:

KQ 2: In patients using intensive insulin therapy (MDI or CSII), does the type of glucose monitoring (rt-CGM vs. SMBG) have a differential effect on process measures, intermediate outcomes, and clinical outcomes in patients with diabetes mellitus (i.e., what is the incremental benefit of rt-CGM in patients already using intensive insulin therapy).

Do these effects differ by:

a. Type 1 or type 2 diabetes status?
b. Age: very young children, adolescents, and adults, including older adults (>65 years)?
c. Pregnancy status: pre-existing type 1 or type 2 diabetes?
d. Intensive insulin delivery: MDI or CSII?

Abbreviations: CSII = continuous subcutaneous insulin infusion; MDI = multiple daily injections; rt-CGM = real-time continuous glucose monitoring; SMBG = self-monitoring of blood glucose