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Procalcitonin-Guided Antibiotic Therapy
Authors: Daniel M. Musher, MD
Gaps in Knowledge and Future Research Needs (1 of 2)
The review identified several knowledge gaps and research needs in the current literature on the use of procalcitonin to guide antibiotic therapy in various patient populations that include:
- The need for conducting research studies to assess the effect of using procalcitonin guidance in patients who are immunocompromised, as this patient population may gain significant clinical benefit from potentially reduced antibiotic usage
- The need for future research on the effects of procalcitonin-guided initiation and discontinuation of antibiotic therapy for pediatric populations in inpatient and outpatient settings
- The need for evaluations of the effects of procalcitonin-guided antibiotic exposure on antibiotic-associated adverse effects, superinfections, or the development of antibiotic resistance in future research studies
Keywords: gaps | research needs | bacterial infection | procalcitonin | antibiotic therapy | patient populations | settings
- Soni NJ, Samson DJ, Galaydick JL, et al. Procalcitonin-Guided Antibiotic Therapy. Comparative Effectiveness Review No. 78 (Prepared by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. HHSA 290-2007-10058-I). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC124-EF. Available at www.effectivehealthcare.ahrq.gov/procalcitonin.cfm.
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