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Procalcitonin-Guided Antibiotic Therapy
Authors: Daniel M. Musher, MD
Gaps in Knowledge and Future Research Needs (2 of 2)
Other knowledge gaps and research needs that were identified in the current literature on the use of procalcitonin to guide antibiotic therapy in various patient populations include:
- The need for additional research about the effect on mortality of reduced antibiotic usage resulting from procalcitonin guidance
- The importance of selecting different comparators such as antibiotic stewardship programs and structured implementation of practice guidelines when conducting comparative effectiveness reviews in the future
- The need to determine the appropriate procalcitonin cutoff level in various patient populations, and the need to evaluate the cost-effectiveness of using procalcitonin to guide antibiotic therapy
Keywords: gaps | research needs | bacterial infection | procalcitonin | antibiotic therapy | patient populations | settings
- Soni NJ, Samson DJ, Galaydick JL, et al. Procalcitonin-Guided Antibiotic Therapy. Comparative Effectiveness Review No. 78 (Prepared by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. HHSA 290-2007-10058-I). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC124-EF. Available at www.effectivehealthcare.ahrq.gov/procalcitonin.cfm.
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