Procalcitonin-Guided Antibiotic Therapy
Uncertainties Related to the Use of Procalcitonin To Guide Antibiotic Therapy
Earlier studies have investigated the potential roles of procalcitonin in diagnosing and managing local and systemic infections. Some evidence indicates that procalcitonin, when compared with other markers, is more specific for bacterial infections, with serum levels rising at the onset of infection and falling rapidly as the infection resolves.
However, the clinical utility of procalcitonin in diagnosing and managing patients with suspected infections remains unclear. This review focused on the clinical utility of procalcitonin in managing patients with suspected infections. Although questions about the clinical utility of procalcitonin in the diagnosis of patients with suspected infections persist, they were not addressed as part of this review.
- Soni NJ, Samson DJ, Galaydick JL, et al. Procalcitonin-Guided Antibiotic Therapy. Comparative Effectiveness Review No. 78 (Prepared by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. HHSA 290-2007-10058-I). Rockville, MD: Agency for Healthcare Research and Quality; August 2012. AHRQ Publication No. 12-EHC124-EF. Available at www.effectivehealthcare.ahrq.gov/procalcitonin.cfm.
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