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Procalcitonin-Guided Antibiotic Therapy

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Uncertainties Related to the Use of Procalcitonin To Guide Antibiotic Therapy

Earlier studies have investigated the potential roles of procalcitonin in diagnosing and managing local and systemic infections. Some evidence indicates that procalcitonin, when compared with other markers, is more specific for bacterial infections, with serum levels rising at the onset of infection and falling rapidly as the infection resolves.

However, the clinical utility of procalcitonin in diagnosing and managing patients with suspected infections remains unclear. This review focused on the clinical utility of procalcitonin in managing patients with suspected infections. Although questions about the clinical utility of procalcitonin in the diagnosis of patients with suspected infections persist, they were not addressed as part of this review.