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Procalcitonin-Guided Antibiotic Therapy

Slide: 9 of 20

The Clinical Question Addressed by This Comparative Effectiveness Review

This comparative effectiveness review attempted to address the key question listed on this slide:

Key Question: In selected populations of patients with suspected local or systemic infection, what are the effects of using procalcitonin measurement plus clinical criteria for infection to guide initiation, discontinuation or a change of antibiotic therapy, when compared with clinical criteria for infection alone on:

  • Intermediate outcomes, such as initiation, discontinuation or change of antibiotic therapy, antibiotic usage, and length of stay?
  • Health outcomes, such as morbidity, mortality, function, quality of life, and adverse events of antibiotic therapy (persistent or recurrent infection and antibiotic resistance)?