Progestogens for Prevention of Preterm Birth
Potential Modifiers of Progestogen Effects on Preterm Birth Outcomes
Modifiers are characteristics that interact with the treatment to change the expected outcome, when compared with those without the characteristic. For the effect of progestogens on preterm birth rates, their severity, and maternal and fetal outcomes, the investigators identified these modifying factors:
- Gestational age of prior spontaneous preterm birth
- Number of prior spontaneous preterm births
- Prior preterm premature rupture of membranes
- Short cervix
- Number of fetuses in multiple gestations
- Preterm labor in the current pregnancy
- Maternal age
- Body mass index
- Conception via reproductive technology
Keywords: preterm birth | progesterone | progestogens | progestins | gestational age | spontaneous preterm birth | premature rupture | PPROM | short cervix | multiple gestations | preterm labor | maternal age | BMI | cerclage | socioeconomics | reproductive technology
- Likis FE, Andrews JC, Woodworth AL, et al. Effectiveness of Progestogens for Prevention of Preterm Birth. Comparative Effectiveness Review No. 74 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2012. AHRQ Publication No. 12-EHC105-EF. Available at www.effectivehealthcare.ahrq.gov/pretermbirth.cfm.
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