Progestogens for Prevention of Preterm Birth
Summary of Study Characteristics Evaluated in the Effectiveness Review: PICOTS
Development of clinical studies of effectiveness of medical interventions is guided by the PICOTS (population, interventions, comparators, outcomes, timing, and setting) framework. These items are critical elements that will help to answer important clinical questions.
In the comparative effectiveness review, the clinical study literature was reviewed and summarized by using the PICOTS framework. The evidence concerning the outcomes identified here was examined in detail, and strength-of-evidence determinations were made only for these key outcomes.
Population: Adult women at risk for preterm birth
- All risk factors
- All formulations, routes, and doses
Comparators: Placebo or no active intervention
- Preterm birth incidence
- Maternal, fetal, and neonatal health outcomes
Timing: Treatment initiated prior to 37 weeks
- Likis FE, Andrews JC, Woodworth AL, et al. Effectiveness of Progestogens for Prevention of Preterm Birth. Comparative Effectiveness Review No. 74 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2012. AHRQ Publication No. 12-EHC105-EF. Available at www.effectivehealthcare.ahrq.gov/pretermbirth.cfm.
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