Progestogens for Prevention of Preterm Birth
Studies and Results by Indication (3 of 3)
Several studies investigated the effects of progestogens in women categorized by a specific risk factor (the indication).
In 3 studies of women with threatened preterm labor, a total of 149 women were studied in treated and control groups. The risk for birth at dates earlier than 37 weeks was reduced by three-fourths. The odds ratio for the pooled studies was 0.26 with a 95-percent confidence interval ranging from 0.10 to 0.49. The strength of evidence is insufficient to permit conclusions about progestogen efficacy in this indication.
Four studies of 385 treated and untreated women with preterm labor measured birth weights. One study of 126 women determined death rates. The evidence is insufficient to permit observations about benefits to birth weight or fetal/neonatal death rates for women with threatened preterm labor.
For populations with varied risk factors, 4 studies examined progestogens in 1,194 women. Two studies measured birth weights for infants of 119 women, and 3 studies determined fetal/neonatal death rates for infants of 269 women. The evidence is insufficient to permit observations about benefits of progestogens for populations with mixed risk factors.
For all other unique indications, represented in single studies, the evidence is insufficient to permit observations about benefits of progestogens.
Keywords: 37 weeks | birth weight | fetal death rate | fetal mortality | neonatal death rate | neonatal mortality | preterm labor | progesterone | progestins | progestogens | preterm birth
- Likis FE, Andrews JC, Woodworth AL, et al. Effectiveness of Progestogens for Prevention of Preterm Birth. Comparative Effectiveness Review No. 74 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2012. AHRQ Publication No. 12-EHC105-EF. Available at www.effectivehealthcare.ahrq.gov/pretermbirth.cfm.
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