Progestogens for Prevention of Preterm Birth
Summary of Benefits: According to Indication/Risk Group (1 of 3)
In women with current singleton pregnancies and a history of spontaneous preterm birth there is evidence of moderate strength that progestogen treatment reduces the risk of preterm birth by one-third and that the treatment may increase birth weights, although the summary result is not statistically significant. Progestogen shows promise for reducing neonatal mortality rates, with an absolute risk reduction of 1.7 percent, yielding a number needed to treat of 58. The strength of evidence in support of this finding is low.
Keywords: preterm birth | progesterone | progestogens | progestins | prior preterm birth | 37 weeks | birth weight | neonatal mortality | fetal mortality
- Likis FE, Andrews JC, Woodworth AL, et al. Effectiveness of Progestogens for Prevention of Preterm Birth. Comparative Effectiveness Review No. 74 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2012. AHRQ Publication No. 12-EHC105-EF. Available at www.effectivehealthcare.ahrq.gov/pretermbirth.cfm.
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