Progestogens for Prevention of Preterm Birth
Evidence About the Adverse Effects of Progestogens
Study withdrawals were similar for treated and control groups.
The most common adverse effects were related to route of administration, such as injection site discomfort and vaginal irritation. The evidence is insufficient to understand the short- and long-term maternal and fetal adverse effects—potential adverse events were not uniformly assessed in the clinical literature. There are no registries to accumulate data on rare or long-term adverse effects for either mothers or children.
- Likis FE, Andrews JC, Woodworth AL, et al. Effectiveness of Progestogens for Prevention of Preterm Birth. Comparative Effectiveness Review No. 74 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2012. AHRQ Publication No. 12-EHC105-EF. Available at www.effectivehealthcare.ahrq.gov/pretermbirth.cfm.
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