Progestogens for Prevention of Preterm Birth
Effects of Modifiers of Outcomes and Safety
None of the studies of maternal characteristics had sufficient statistical precision to determine the effects of modifiers on benefits and adverse effects of progestogens. No data inform whether effectiveness of progestogen treatment varies among women with prior preterm premature rupture of membranes, cerclage, uterine malformation, or conceptions via assisted reproduction technology when compared with other women.
No dose-finding studies focused on efficacy or effectiveness were identified in this review. No literature addresses whether adherence or acceptability to patients varies by formulation, dose, or route.
For all the modifiers evaluated, the evidence is insufficient to guide care.
Keywords: preterm birth | progesterone | progestogens | progestins | PPROM | cerclage | uterine malformation | assisted reproduction | formulation | dose
- Likis FE, Andrews JC, Woodworth AL, et al. Effectiveness of Progestogens for Prevention of Preterm Birth. Comparative Effectiveness Review No. 74 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2012. AHRQ Publication No. 12-EHC105-EF. Available at www.effectivehealthcare.ahrq.gov/pretermbirth.cfm.
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