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Progestogens for Prevention of Preterm Birth

Slide: 26 of 29

Effects of Modifiers of Outcomes and Safety

None of the studies of maternal characteristics had sufficient statistical precision to determine the effects of modifiers on benefits and adverse effects of progestogens. No data inform whether effectiveness of progestogen treatment varies among women with prior preterm premature rupture of membranes, cerclage, uterine malformation, or conceptions via assisted reproduction technology when compared with other women.

No dose-finding studies focused on efficacy or effectiveness were identified in this review. No literature addresses whether adherence or acceptability to patients varies by formulation, dose, or route.

For all the modifiers evaluated, the evidence is insufficient to guide care.