Progestogens for Prevention of Preterm Birth
Conclusions About Benefits and Adverse Effects
For women with prior spontaneous preterm birth and current singleton pregnancies, progestogens reduce the risk of preterm birth. There is no benefit for women with multiple gestations. For all other indications, the evidence is insufficient to guide care.
The incidence of rare adverse events is not known, and the effects of modifiers are unknown.
The evidence is insufficient to know whether progestogen use prevents morbidity or promotes normal childhood development.
- Likis FE, Andrews JC, Woodworth AL, et al. Effectiveness of Progestogens for Prevention of Preterm Birth. Comparative Effectiveness Review No. 74 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2012. AHRQ Publication No. 12-EHC105-EF. Available at www.effectivehealthcare.ahrq.gov/pretermbirth.cfm.
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