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Progestogens for Prevention of Preterm Birth

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What To Discuss With Your Patients and Their Caregivers

Progestogens reduce the risk of preterm birth for women who previously had a spontaneous preterm birth and who currently have a singleton pregnancy. There is some evidence of benefit for women with short cervix. They do not prevent preterm birth for multiple gestations.

There is little evidence about benefits of using progestogens for women with preterm labor or other risk factors for preterm birth. The evidence about choosing the oral, injection, or vaginal method for treatment is limited.

It is not known if progestogens will provide short- or long-term benefits to the infant or mother, other than delaying birth, and there is little evidence about short-and long-term harms.