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Treatment for Hepatitis C Virus Infection in Adults: Comparative Effectiveness

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Treatment for Hepatitis C Virus Infection in Adults: Comparative Effectiveness

This slide set is based on a comparative effectiveness review (CER), Treatment for Hepatitis C Virus Infection in Adults: Comparative Effectiveness, Comparative Effectiveness Review No. 76, which was developed by the Oregon Evidence-based Practice Center, Portland, OR, for the Agency for Healthcare Research and Quality under Contract No. 290-2007-10057-I and is available online at www.effectivehealthcare.ahrq.gov/hepctreatment.cfm.

CERs are comprehensive systematic reviews of the literature that usually compare two or more types of interventions with usual care for the same disease. For this CER, the existing body of evidence on the relative benefits and adverse effects of currently available therapies for hepatitis C virus (HCV) infection in adults was reviewed. The literature included in this review was identified in searches for studies in the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, and Ovid MEDLINE® using relevant search terms and covering the period from 1947 to April 2012. Unpublished trials were sought by searching clinical trial registries and grants databases. Studies in adults with chronic HCV infection who had no prior antiviral treatment for HCV were included. The review did not include children and pregnant women, as well as post-transplant, hemodialysis, and HIV-infected patients in its evaluation. Intermediate outcomes assessed in the review were sustained virologic response and histological improvement. Assessed final clinical outcomes included morbidity and mortality from HCV infection, quality of life, and harms of antiviral therapies for HCV infection.