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Treatment for Hepatitis C Virus Infection in Adults: Comparative Effectiveness

Slide: 32 of 34

Gaps in Knowledge (2 of 2)

Randomized, controlled trials that enroll broader populations of patients infected with the hepatitis C virus and have medical and psychological comorbidities, as frequently encountered in clinical practice, are needed to better understand comparative effectiveness, rather than just comparative efficacy.

Studies on the effects of achieving a sustained virologic response on long-term quality of life are unclear. Studies addressing these effects would be very helpful for understanding other potential clinical benefits of antiviral therapy. However, a significant challenge is whether it is possible to ethically blind patients to their virologic status, which may have an important impact on assessments of quality of life.