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Drug Therapy for Rheumatoid Arthritis in Adults

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Clinically Significant Outcomes of Interest in the Comparative Effectiveness Review

In analyzing the clinical study evidence, reviewers focused on these outcomes of benefit and corresponding assessment instruments or scoring indices:

  • Disease activity and symptoms were evaluated using American College of Rheumatology response scores (ACR 20/50/70) and DAS and DAS28 disease activity scores.
  • Radiographic changes were measured using the Sharp/van der Heijde Method (SHS) for scoring radiographs.
  • Functional capacity was evaluated by the Health Assessment Questionnaire (HAQ) and the disability index of HAQ (HAQ-DI).
  • Quality of life was measured using the SF-36 and EQ-5D questionnaires.