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Drug Therapy for Rheumatoid Arthritis in Adults

Slide: 40 of 45

Conclusions (1 of 4)

For patients with early rheumatoid arthritis (RA) who have not been treated with methotrexate (MTX), treatment with either MTX or a biologic disease-modifying anti-rheumatic drug (DMARD) provides similar benefits for symptoms and function. However, biologic DMARDs are more effective at limiting radiographic evidence of progression.

The evidence is too limited to permit conclusions about whether one combination strategy is better than another in treating early RA (<3 years’ duration).

Evidence is accumulating that biologic DMARDs as a class, offer greater likelihood of remission in patients with longstanding active disease than do oral ones.