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Drug Therapy for Rheumatoid Arthritis in Adults

Slide: 7 of 45

Oral DMARDs Included in the Comparative Effectiveness Review

The oral disease-modifying anti-rheumatic drugs that have been studied for treatment of rheumatoid arthritis and were included in the comparative effectiveness review are:

Hydroxychloroquine: Its target of activity is uncertain but likely is T-lymphocytes.

Leflunomide: Its target of activity is pyridine synthesis.

Methotrexate: Its target of activity is dihydrofolate reductase and folate metabolism.

Sulfasalazine: Its target of activity is uncertain but may be multifactorial, including impairment of lymphocyte function and cytokine synthesis.