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Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis

Slide: 18 of 37

rhGH Effects on Health Outcomes Reported in Controlled Trials

Health outcomes of interest include hospitalization rate, antibiotic use, pulmonary exacerbations, HRQoL, bone consequences and mortality. In studies of rhGH treatment of patients with CF, the hospitalization rate was reduced when compared with controls by 1.62 per year. There is insufficient evidence about antibiotic use, pulmonary exacerbations, and HRQoL to estimate an effect of treatment. Bone consequences and mortality were not reported in any rhGH trial.