Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Clinical Questions Addressed by the CER (2 of 4)
In preparing the report on which this CME activity is based, the authors aimed to answer six KQs. KQs 1b and 2 are listed below:
KQ 1b. How do these nonpharmacologic treatments compare with pharmacologic treatments in efficacy or effectiveness in treating acute-phase depressive symptoms after two or more failed adequate trials?
KQ 2. For adults with TRD, do nonpharmacologic interventions differ in their efficacy or effectiveness for maintaining response or remission (e.g., preventing relapse or recurrence), whether as a single treatment or part of a combination treatment?
- Gaynes BN, Lux L, Lloyd S, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33 (Prepared by RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC056-EF. Available at: http://www.effectivehealthcare.ahrq.gov/trd.cfm.
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