Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Clinical Questions Addressed by the CER (4 of 4)
In preparing the report on which this CME activity is based, the authors aimed to answer six KQs. KQs 5 and 6 are listed below:
KQ 5. How do the efficacy, effectiveness, or harms of treatment with nonpharmacologic treatments for TRD differ for the following subpopulations:
- Elderly or very elderly patients; other demographic groups (defined by age, ethnic or racial groups, and sex)?
- Patients with medical comorbidities (e.g., seizure history, stroke, diabetes, dementia, perinatal depression, ischemic heart disease, cancer)?
KQ 6. For adults with TRD, do nonpharmacologic interventions differ in regard to other health-related outcomes (e.g., quality of life)?
- Gaynes BN, Lux L, Lloyd S, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33 (Prepared by RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC056-EF. Available at: http://www.effectivehealthcare.ahrq.gov/trd.cfm.
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