First- and Second-Generation Antipsychotics for Children and Young Adults
Clinically Significant Outcomes of Interest in the Comparative Effectiveness Review
Both core illness symptoms and nonspecific symptoms were of interest in the systematic review.
A wide variety of common psychiatric assessment instruments are used to evaluate symptoms in studies of pediatric use of antipsychotics. These included:
- The Aberrant Behavior Checklist (ABC), which evaluates treatment effects on profoundly mentally retarded participants
- The Brief Psychiatric Rating Scale–Children (BPRS-C), which evaluates childhood psychiatric disorders and response to treatment
- The Children’s Depression Rating Scale (CDRS), which evaluates the severity of depression in children 6–12 years of age
- The Children’s Global Assessment Scale (CGAS), which is an overall measure of disturbance used for children 4–16 years of age
- The Clinical Global Impressions (CGI), which evaluates the global rating of severity (-S), improvement (-I), or overall impression
- The Nisonger Child Behavior Rating Form (NCBRF), which evaluates childhood problems because of mental retardation
- The Overt Aggression Scale (OAS), which evaluates physical and verbal aggressive behaviors
- The Positive and Negative Syndrome Scale (PANSS), which evaluates positive and negative symptoms in schizophrenia
- The Young Mania Rating Scale (YMRS), which evaluates the severity (not diagnosis) of mania
Keywords: antipsychotics | pediatrics | first-generation antipsychotics | second-generation antipsychotics | typical antipsychotics | atypical antipsychotics | ABC | BPRS-C | CDRS | CGAS | CGI | NCBRF | OAS | PANSS | YMRS
- Seida J, Schouten J, Mousavi S, et al. First- and Second-Generation Antipsychotics for Children and Young Adults. Comparative Effectiveness Review No. 39 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. 290-2007-10021). Rockville, MD: Agency for Healthcare Research and Quality; February 2012. AHRQ Publication No. 11(12)-EHC077-EF. Available at www.effectivehealthcare.ahrq.gov/pedantipsych.cfm.
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