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First- and Second-Generation Antipsychotics for Children and Young Adults

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Adverse Events of Interest in the Comparative Effectiveness Review

Adverse events data extracted from published studies included:

  • Mortality
  • Cardiac and cerebrovascular events
  • Weight and body composition
  • Dyslipidemia
  • Insulin resistance and diabetes
  • Prolactin-related and sexual effects
  • Neuromotor (extrapyramidal)
  • Sedation
  • Liver toxicity
  • Neutropenia and agranulocytosis
  • Thyroid dysfunction
  • Seizures
  • Neuroleptic malignant syndrome
  • Constipation
  • Exercise intolerance
  • Precocious puberty
  • Behavioral effects
  • Dermatological effects

For adverse events reporting, standardized instruments that evaluate extrapyramidal symptoms are also used in clinical trials.