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First- and Second-Generation Antipsychotics for Children and Young Adults

Slide: 4 of 43

Introduction to Antipsychotics in Pediatric Use (2 of 4)

First-generation antipsychotics (FGAs) are associated with side effects that are difficult to manage and in some cases are irreversible. Neurological side effects include extrapyramidal system movement disorders. Some serious adverse effects that occur with use of FGAs are tardive dyskinesia with repetitive, involuntary muscle movements; akathisia, characterized by restlessness; and the inability to initiate movement, a Parkinson’s disease-like symptom. Development of the second-generation antipsychotics was driven by the desire to limit neuromotor adverse effects.