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Second-Generation Antidepressants for Treating Adult Depression—An Update

Slide: 15 of 28

Comparative Effectiveness of Second-Generation Antidepressants in Continuation and Maintenance Phases

This portion (slides 15–16) of the presentation addresses two key aspects of treating patients with major depressive disorder (MDD). First, the research presented in this section addresses maintenance of remissions and prevention of relapses or recurrences for patients who have responded to antidepressant treatment; the second issue the research addresses focuses on ongoing depressive disease for those who have not responded to such therapy or who have experienced relapses or new episodes. For patients who have responded, two subquestions are important: the efficacy or effectiveness of (1) continuing the initial (existing) medication or (2) switching to a different one. For patients who have not responded to treatment, the studies focus on using different antidepressants.