Second-Generation Antidepressants for Treating Adult Depression—An Update
Background: Treatment for Depression
Pharmacotherapy dominates the medical management of depressive disorders, including first-generation and the more recently developed second-generation antidepressants. First-generation antidepressants include tricyclic antidepressants and monoamine oxidase inhibitors. Second-generation antidepressants dominate the medical management of depressive disorders and include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), selective serotonin and norepinephrine reuptake inhibitors (SSNRIs), and other drugs with related mechanisms of action that selectively target neurotransmitters. The mechanism of action of most of these agents is poorly understood, but they most likely work through their effects on neurotransmitters such as serotonin, norepinephrine, or dopamine in the central nervous system.
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