Off-Label Use of Atypical Antipsychotics: An Update
Adverse Effects of Atypical Antipsychotics
The reviewed data were restricted to reports in studies of off-label use of atypical antipsychotics. With the exception of dementia, which is associated with older age, the adverse effects observed were not expected to be influenced by the diagnosis. Evidence was analyzed for two separate groups: elderly patients with dementia and adults aged 18–64.
The atypical antipsychotic clozapine was not included in the review; clozapine can only be prescribed in a system that requires weekly monitoring for bone marrow-suppression disorders before providing the drug.
Keywords: antipsychotics | atypical antipsychotics | off-label | second generation | adverse effects | clozapine
- Maglione M, Ruelaz Maher A, Hu J, et al. Off-Label Use of Atypical Antipsychotics: An Update. Comparative Effectiveness Review No. 43 (Prepared by the Southern California RAND Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11(12)-EHC087-EF. Available at www.effectivehealthcare.ahrq.gov/offlabelantipsych.cfm.
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