Off-Label Use of Atypical Antipsychotics: An Update
Summary of Adverse Effects in Adults (2 of 2)
The risk of extrapyramidal symptoms is elevated with aripiprazole (NNH = 11; akathisia, NNH =7), quetiapine (NNH = 36), and ziprasidone (NNH = 24) in adults (ages 18–64). The strength of evidence for these findings is low.
The risks of extrapyramidal symptoms with olanzapine and aripiprazole are about one-fourth of the risks for adult patients taking typical antipsychotics. The strength of evidence for these findings is low.
Atypical antipsychotics are associated with sedative effects and fatigue (sedation NNH = 3 for quetiapine, whereas others range from 6–11; fatigue NNH = 14–19) in adults. The strength of evidence for these findings is moderate.
Keywords: antipsychotics | atypical antipsychotics | off-label | second generation | extrapyramidal symptoms | EPS | olanzapine | aripiprazole | sedation | fatigue
- Maglione M, Ruelaz Maher A, Hu J, et al. Off-Label Use of Atypical Antipsychotics: An Update. Comparative Effectiveness Review No. 43 (Prepared by the Southern California RAND Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11(12)-EHC087-EF. Available at www.effectivehealthcare.ahrq.gov/offlabelantipsych.cfm.
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